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New Human Study Confirms Digexin’s® Regularity and Mood Benefits

Newly published clinical study reaffirms Digexin’s efficacy in improving regularity, speed of transit, physical comfort, and mental health.

“Constipation, a prevalent gastrointestinal dysfunction, not only restricts social activities but also impairs both mental and physical health,” explain the study authors. “Our latest research, a randomized, double-blind, placebo-controlled human clinical trial, confirms that Digexin stands out as a safe and effective supplement. It significantly enhances gut health by improving gastrointestinal transit times, as demonstrated by the innovative ‘blue poo’ test, which tracks digestion and bowel movement speeds.”

The “Blue Poo” test directly measures the effects of Digexin on transit times, revealing in this particular study that participants in the Digexin group experienced nearly four hours faster transit than those in the placebo group.

The study was aimed at reevaluating the effectiveness and tolerability of Digexin, a blend of Withania somnifera root and Abelmoschus esculentus fruit extracts. Engaging 135 participants aged 25 to 60 over 60 days, the study distributed doses of 300 mg and 500 mg of Digexin, and compared them against placebo. Assessments were made using various scales including PAC-SYM, PAC-QOL, GSRS scores, gastrointestinal transit time, and complete spontaneous bowel movement scores, along with a comprehensive analysis of serum biomarkers. Results revealed substantial improvements in constipation symptoms, quality of life, bowel function, and mental health from as early as day 7.1

“We saw some pretty impressive improvements across the board. People reported feeling better in terms of their digestive symptoms, overall quality of life, and even saw faster digestive transit times. Plus, they were going to the bathroom more regularly, which is always a good sign. But it wasn’t just about digestion. Sleep got better, and feelings of depression and anxiety eased up. And most importantly, the blood tests showed significant positive changes, validating that what people were reporting was supported by biomarker evidence,” said Eric Anderson, Managing Director, NXT USA.

“Digexin not only improved symptoms throughout the GI tract – from reflux and indigestion to bloating and constipation – but the effect sizes were substantial, almost eliminating symptoms completely in some cases,” noted Eric Withee of Freemen Nutra, the US & European distributor of Digexin. “This is made possible by providing direct benefits to the GI tract while simultaneously helping shift the body away from the sympathetic, or ‘fight or flight’ tone, to the parasympathetic state more conducive to digestion.”

Digexin is currently available Globally from NXT USA, Inc., and also in the US and Europe through Freemen Nutra.  Visit NXT-USA and Freemen Nutra at VitaFoods in Geneva, Switzerland, booth E122 from May 14 – 16, 2024 to learn more.


1. Singh, G., Dixit, I., Kalman, D., & Gogineni, N. T. (2024). A Novel Herbal Composition Alleviates Functional Constipation, Reduces Gastrointestinal Transit Time, and Improves Bowel Function in Adults: A Double-Blind, Randomized Clinical Study. Journal of the American Nutrition Association, 1–14.



Media Inquiries:
Becky Wright
WrightOn Marketing & Communications


 About NXT USA:
NXT-USA provides unique ingredients and combinations based on clinical validation. These proprietary ingredients address key consumer concerns in energy, brain, joint, and digestive health. Its mission is to deliver novel ingredient solutions that enable manufacturers to create impactful products that cater to the modern consumer and gain attention on store shelves.



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