Clinical Studies
Digexin is backed by two double blind placebo controlled human studies as well as open label and placebo comparison studies with results showing improved digestion and enhanced mood.
STUDY 1
In a recently published DBPC human clinical study, 14-day supplementation with Digexin was shown to be tolerable and effective in relieving constipation and improving several associated symptoms, such as gastrointestinal function, bowel clearance, stress, sleep, and quality of life of the study volunteers. Forty-eight male and female participants (age: 25 to 60 years) with functional constipation were randomized into placebo, 300 or 500 mg of Digexin groups, and supplemented for 14 consecutive days. Digexin supplementation significantly reduced the Patient Assessment of Constipation-Symptoms (PAC-SYM), Patient Assessment of Constipation-Quality of Life (PAC-QOL), and promoted faster and more complete digestion (Complete Evacuation). Further, supplementation also improved sleep quality and reduced stress, with subjects showing significant improvements in serum serotonin, gastrin, IL-6, IL-10, and cortisol.
Symptoms of Constipation
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Intergroup (vs placebo): $=p<0.05
Quality of Life Impact
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Complete Evacuation
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Sleep Quality
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Stress Levels
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Serotonin
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Cortisol
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Punukollu, Raghu Sarath, et al. “A Blend of Withania Somnifera (L.) Dunal Root and Abelmoschus Esculentus (L.) Moench Fruit Extracts Relieves Constipation and Improves Bowel Function: A Proof-of-concept Clinical Investigation.” Journal of Ethnopharmacology, vol. 318, part B, 116997, Jan. 2024. www.sciencedirect.com
STUDY 2
In a recently concluded 60-day DBPC human clinical study of 135 healthy male and female subjects between 25 and 60 years old, Digexin (both 300mg and 500mg) was affirmed to be safe and effective. Subjects experienced a significant reduction in constipation symptoms as well as improvements in depression, anxiety, and sleep profiles. Significantly, Gastrointestinal Transit Time (GIT) was assessed via blue dye method and subjects in both the 300mg and 500mg groups demonstrated a statistically reduced transit time as compared with baseline and placebo.
Self-administered questionnaires were assessed and revealed both doses:
- Reduced constipation symptoms
- Improved sense of complete evacuation
- Improved quality of life based on significantly reducing physical and psychological discomfort, worries, and concerns
- Improved sleep quality
NXT USA is in search of early-stage partners to start the process of creating finished products. Further, a second larger clinical trial is currently underway to help validate Digexin’s benefits.
*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
Digexin News
NXT USA, a new company developing unique nutraceutical solutions, launched their novel digestive health solution called Digexin at SupplySide West.
Backed by a new human proof-of-concept study showing improved digestion and enhanced mood, NXT USA is searching for early-stage partners to start creating finished products.
