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Clinical Studies

Digexin is backed by two double blind placebo controlled human studies as well as open label and placebo comparison studies with results showing improved digestion and enhanced mood. These are benefits that users can experience directly, offering genuine relief and improvements in their daily lives.

Study 1

Our first published human study highlighted a notable decrease in constipation symptoms after just 7 days, with participants experiencing improved bowel function and faster gastrointestinal transit. Significant improvements were observed in constipation symptoms, gastrointestinal function, bowel clearance, stress, sleep, and quality of life. Importantly, Digexin significantly enhanced mental health, improving sleep quality and reducing depression and anxiety symptoms.

Study 2

In our second human study (pending publication) on Digexin we included a larger population over a longer period of time and reconfirmed Digexin’s remarkable efficacy in enhancing gastrointestinal health, significantly improving bowel function and alleviating common constipation symptoms such as bloating and discomfort. Significant new findings were documented in improved gastrointestinal transit time. Additionally, improvements in sleep quality, reduced symptoms of depression and anxiety, and significant changes in serum biomarkers were observed.

SYMPTOMS OF CONSTIPATION

Study 1

Study 1- Symptoms of constipation

Intragroup (from baseline): *=p<0.05
Intergroup (vs placebo): $=p<0.05

Study 2

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Digexin eliminates the symptoms associated with constipation such as discomfort, pain, cramps, and bloating. Promoting faster and more complete digestion for better movement and absorption, Digexin effectively promotes regularity.

DECREASED BLOATING

Study 1

Pac-sym bloating 5

Intragroup (from baseline): *=p<0.05
Intergroup (vs placebo): $=p<0.05

Study 2

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In both human studies, we saw that Digexin significantly reduced the sense of being bloated—that sensation of having gas or air in the stomach that is such a common complaint among folks with chronic gut issues.

COMPLETE BOWEL MOVEMENTS

Study 1

study1-complete evac

Intragroup (from baseline): *=p<0.05
Intergroup (vs placebo): $=p<0.05

Study 2

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Digexin significantly boosts regularity, promoting smoother and more complete digestive processes. The result is regular daily bowel movements, bringing that sense of having completely emptied your bowels that comes with having a healthy gut and well-run GI system.

INCREASED SEROTONIN

Study 1

Study1-serotonin

Intragroup (from baseline): *=p<0.05
Intergroup (vs placebo): $=p<0.05

Study 2

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Beyond physical benefits, Digexin positively impacts mental well-being by promoting serotonin production, leading to improved mood and overall quality of life through better physical and emotional comfort.

DECREASED CORTISOL

Study 1

Study 1- cortisol

Intragroup (from baseline): *=p<0.05
Intergroup (vs placebo): $=p<0.05

Study 2

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Helping to reduce the amount of cortisol the body produces, Digexin helps improve quality of life by removing negative mental, emotional, and psychosocial effects of constipation.

IMPROVED QUALITY OF SLEEP

Study 1

Study1-sleep quality2

Intragroup (from baseline): *=p<0.05
Intergroup (vs placebo): $=p<0.05

Study 2

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Sleep and GI health are tightly linked. Digexin helps break the fluctuating cycle in GI disorders and helps long term health.

DECREASED FEELINGS OF STRESS

Study 1

Study1-Stress levels

Intragroup (from baseline): *=p<0.05
Intergroup (vs placebo): $=p<0.05

Study 2

blurred_chart4

Stress is linked to various digestive issues and reducing stress may help prevent GI relapse. By helping to reduce stress, Digexin helps improve quality of life by removing negative mental, emotional, and psychosocial effects of constipation.

Mechanism in Action:
Transit Time

By enhancing the speed and efficiency of digestion, Digexin ensures better movement and absorption of nutrients, leading to optimal gastrointestinal health. One of our main ingredients, Ashwaganda, also known as Winter Cherry, helps the body increase serotonin production which then stimulates peristalsis—the movement of food through the digestive tract. Using the Blue Poo test*,  participants saw a significant reduction in transit time!

*Article citation: Asnicar F, Leeming ER, Dimidi E, Mazidi M, Franks PW, Al Khatib H, Valdes AM, Davies R, Bakker E, Francis L, Chan A, Gibson R, Hadjigeorgiou G, Wolf J, Spector TD, Segata N, Berry SE. Blue poo: impact of gut transit time on the gut microbiome using a novel marker. Gut. 2021 Sep;70(9):1665-1674. doi: 10.1136/gutjnl-2020-323877. Epub 2021 Mar 15. PMID: 33722860; PMCID: PMC8349893.

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Self-administered questionnaires were assessed and revealed both doses:

  • Reduced constipation symptoms
  • Improved sense of complete evacuation
  • Improved quality of life based on significantly reducing physical and psychological discomfort, worries, and concerns
  • Improved sleep quality

NXT USA is in search of early-stage partners to start the process of creating finished products.

*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

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