Clinically Demonstrated NAD+ Support
BluNADBooster® is a plant-based NAD+ solution with a dual mechanism of action - supporting natural NAD+ production while helping reduce its breakdown.
Its effects were demonstrated in a randomized, double-blind, placebo-controlled clinical trial in healthy aging adults, published in Journal of Functional Foods (2025).
↑ Increase in NAD+ Levels
Significant elevation in circulating NAD+ levels was observed in healthy aging adults compared to baseline.
↓ Reduce NAD+ Breakdown
BluNADBooster helps modulate CD38 activity, a key enzyme responsible for accelerated NAD+ degradation during aging.
↓ Reduce Inflammatory Biomarkers
BluNADBooster supplementation significantly reduced TNF-α levels, a key inflammatory cytokine associated with aging and metabolic stress.
↑ Improve Functional Health Indicators
Participants demonstrated improvements in quality-of-life markers, mitochondrial health indicators, and physical performance assessments during the study period.
Clinically Demonstrated NAD+ Support
BluNADBooster® is a plant-based NAD+ solution with a dual mechanism of action - supporting natural NAD+ production while helping reduce its breakdown.
Its effects were demonstrated in a randomized, double-blind, placebo-controlled clinical trial in healthy aging adults, published in Journal of Functional Foods (2025).
Study Facts
Inside the Clinical Study
BluNADBooster® was developed to address two key contributors to declining NAD+ levels:
- Supporting NAD+ biosynthesis
- Modulating CD38 activity to help preserve intracellular NAD+
To evaluate these effects in humans, a randomized, double-blind, placebo-controlled clinical trial was conducted in healthy aging adults.
Study Facts
Inside the Clinical Study
BluNADBooster® was developed to address two key contributors to declining NAD+ levels:
- Supporting NAD+ biosynthesis
- Modulating CD38 activity to help preserve intracellular NAD+
To evaluate these effects in humans, a randomized, double-blind, placebo-controlled clinical trial was conducted in healthy aging adults.
NAD+ Levels in Blood
BluNADBooster® supplementation significantly increased circulating NAD+ levels in healthy aging adults. At day 60, BluNADBooster increased NAD+ levels by 26.48%, compared with 22.69% for NR, while the BluNADBooster + NR combination increased NAD+ levels by 31.76%.
These findings confirm that BluNADBooster effectively supports NAD+ levels through a standardized botanical formulation.
Reduction in CD38 Activity
BluNADBooster® supplementation significantly reduced CD38 activity, a key enzyme responsible for accelerated NAD+ degradation. At day 60, BluNADBooster reduced CD38 activity by 17.98%, while NR alone showed minimal change.
These findings demonstrate measurable modulation of an NAD-consuming pathway, reinforcing BluNADBooster’s dual-action profile: supporting NAD+ production while helping limit NAD+ degradation.
Reduction in Inflammatory Signaling (TNF-α)
BluNADBooster® supplementation significantly reduced TNF-α levels, a key cytokine involved in inflammatory signaling associated with aging and metabolic stress. At day 60, TNF-α levels decreased by 13.2% with BluNADBooster, compared with 11.1% for NR, while the BluNADBooster + NR combination reduced levels by 17.3%.
These findings suggest that BluNADBooster may contribute to improved inflammatory balance alongside its effects on NAD⁺ metabolism.
Improvements in Physical and Cognitive Performance
Participants receiving BluNADBooster® demonstrated measurable improvements in both physical endurance and cognitive performance during the study period. Together, these findings highlight the potential of BluNADBooster to support multiple functional aspects of healthy aging.
In the Six-Minute Walk Test, the combination group improved walking distance by 9.94%, indicating enhanced functional mobility.
Cognitive performance was assessed using the MMSE-2 score, which increased by 16.45% in the combination group, reflecting improvements in memory and mental processing.
Improvements in Physical and Cognitive Performance
Participants receiving BluNADBooster® demonstrated measurable improvements in both physical endurance and cognitive performance during the study period. In the Six-Minute Walk Test, the combination group improved walking distance by 9.94%, indicating enhanced functional mobility.
In parallel, cognitive performance assessed using the MMSE-2 score increased by 16.45% in the combination group, reflecting improvements in memory and mental processing. Together, these findings highlight the potential of BluNADBooster to support multiple functional aspects of healthy aging.
Improvements in Physical and Cognitive Performance
Participants receiving BluNADBooster® demonstrated measurable improvements in both physical endurance and cognitive performance during the study period. In the six-minute walk test, the BluNADBooster® + NR combination improved walking distance by 9.94%, indicating enhanced functional mobility.
In parallel, cognitive performance assessed using the MMSE-2 score increased by 16.45% in the combination group, reflecting improvements in memory and mental processing. Together, these findings highlight the potential of BluNADBooster to support multiple functional aspects of healthy aging.
Botanical Innovation, Clinically Validated
BluNADBooster® is a proprietary blend of standardized botanical extracts derived from:
- Punica granatum (pomegranate) whole fruit
- Tagetes erecta (marigold) flower
Developed through extensive botanical screening and mechanistic research, BluNADBooster represents a plant-derived strategy for supporting NAD+ metabolism through complementary biological pathways rather than relying solely on precursor supplementation.
This dual-pathway botanical approach provides a differentiated, formulation-ready ingredient for brands seeking clinically validated NAD+ support.
Botanical Innovation, Clinically Validated
BluNADBooster® is a proprietary blend of standardized botanical extracts derived from:
- Punica granatum (pomegranate) whole fruit
- Tagetes erecta (marigold) flower
Developed through extensive botanical screening and mechanistic research, BluNADBooster represents a plant-derived strategy for supporting NAD+ metabolism through complementary biological pathways rather than relying solely on precursor supplementation.
This dual-pathway botanical approach provides a differentiated, formulation-ready ingredient for brands seeking clinically validated NAD+ support.
Safety & Tolerability
Well Tolerated in Human Clinical Study
BluNADBooster supplementation was well tolerated throughout the clinical study. No serious adverse events were reported, and laboratory parameters, vital signs, and safety assessments remained within normal ranges during the intervention period.
The safety profile of BluNADBooster is further supported by preclinical evaluations and rigorous toxicity assessments. The botanical ingredients used in the formulation have a long history of safe use and comply with relevant regulatory standards, providing additional assurance for use in dietary supplement formulations.
Safety & Tolerability
Well Tolerated in Human Clinical Study
BluNADBooster supplementation was well tolerated throughout the clinical study. No serious adverse events were reported, and laboratory parameters, vital signs, and safety assessments remained within normal ranges during the intervention period.
The safety profile of BluNADBooster is further supported by preclinical evaluations and rigorous toxicity assessments. The botanical ingredients used in the formulation have a long history of safe use and comply with relevant regulatory standards, providing additional assurance for use in dietary supplement formulations.
*Full Citation: Bandi VK, Chundru VK, Yarasani A, et al. Comparative efficacy of a standardized herbal composition LN22199, nicotinamide riboside, and their combination on NAD+ metabolism in healthy aging adults. Journal of Functional Foods. 2025;135:107115. doi:10.1016/j.jff.2025.107115
*Full Citation: Bandi VK, Chundru VK, Yarasani A, et al. Comparative efficacy of a standardized herbal composition LN22199, nicotinamide riboside, and their combination on NAD+ metabolism in healthy aging adults. Journal of Functional Foods. 2025;135:107115. doi:10.1016/j.jff.2025.107115
Natural Activation & Smarter Preservation
Natural Activation & Smarter Preservation